It seems that as ‘Opera version 10.xx’ has decided to move its file positions yet again to the far flung reaches of my PC resulting in CCleaner’ not cleaning all the ‘Opera’ folders with internet information in them correctly. I am using ‘Vista Premium’ with all updates applied. On my PC the 'Opera' paths that are not cleaned are as follows:

C:\Users\me\appdata\local\opera\opera\opcacahe\*.*
C:\Users\me\appdata\ocal\opera\opera\tempory_downloads\*.*
C:\Users\me\appdata\local\opera\opera\vps\*.*

This is for a single user setup, if you have multiple users may the Lord have mercy on you soul.

New skins seem to be installed in: C:\Users\ThisUser\AppData\Roaming\Opera\Opera\skin

I hope this helps:

Regards, & thanks for a great product.