Save this into winapp2.ini. If you don't have a winapp2.ini file create it. winapp2.ini is in the same folder as ccleaner.exe:
CODE
[Opera 8 (Single User)]
LangSecRef=3027
Detect=HKCU\Software\Opera Software
Default=True
FileKey1=%ProgramFiles%\Opera\profile|COOKIES4.DAT
FileKey2=%ProgramFiles%\Opera\profile|cookies4.dat.sbsd.bak
FileKey3=%ProgramFiles%\Opera\profile|GLOBAL.DAT
FileKey4=%ProgramFiles%\Opera\profile|OPERA6.ADR.SBSD.BAK
FileKey5=%ProgramFiles%\Opera\profile\CACHE4|*.*
FileKey6=%ProgramFiles%\Opera\profile\cacheOp|*.*
Edit:
Also get into the habit of installing programs into their default directory that their setup program suggests, since that's where CCleaner will look to clean their litter.