Memory optimisers are a waste of time and should never be used.
Now for the tip that I found in one of my other forums which most of the experts here probably already know about.
Open Taskmanager and leave it open.
Open my computer,minimize and watch explorer's mem usage drop.
Maximize and explorer will go to about half of it's original mem usage.
Open a large word document and do the same.Winword.exe will dramatically drop it's memory usage,same as for IE.
Works on quite a few apps I've tried.